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While the effects on the development of levodopa-related motor complications require long-term trials in de-novo subjects, the EPSILON study of early opicapone adjunct in levodopa-treated subjects without motor complications has recently provided evidence for beneficial effects on motor control without increasing motor complication risk over 76 weeks

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Thereafter, 90 min was allowed for recovery of muscle from insertion trauma

Another misconception is that BMI is the only criterion

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10.1042/BSR20100065 175 MukherjeeS.SarkarR.BiswasJ.RoyM