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High-response percentages also do not prove that the same results will occur: With an unverified product Without medical monitoring Outside the trial duration In people excluded from the study After treatment ends In combination with unstudied substances Claims that retatrutide guarantees a particular percentage of weight loss are misleading

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A large JAMA Surgery study found that over 2 years, mean total costs were higher for GLP-1 receptor agonists than for metabolic/bariatric surgery: about $63,483 for GLP-1 therapy vs $51,794 for surgery