doi: 10.1177/1533317510375083 34 BrooksB
The main antidiabetic drugs used clinically are thiazolidinediones (e.g., troglitazone, rosiglitazone), metformin, sulphonylureas and glinides (10)
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Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid- peptide-induced impairment of spatial learning and memory in rats
Higher doses may lead to stronger symptoms, which is why treatment usually begins with a lower dose that is gradually increased so the body has time to adjust
Given their effectiveness in controlling blood glucose and HbA1c levels, with additional weight loss benefits and minimal intrinsic risk of hypoglycemic episodes, GLP-1 RAs are now considered the first-line injectables for optimal glucose control in diabetic patients even before insulin treatment [18]