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Semaglutide injection activates the GLP-1 receptor with high selectivity, triggering cascading signals that affect appetite centers in the hypothalamus and the nucleus tractus solitarius

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FIDELIO-DKD demonstrated a significant reduction in kidney failure and CV outcomes (HR 0.82 for the primary kidney composite), complemented by FIGARO-DKD and consolidated in the FIDELITY pooled analysis, which showed a 23% reduction in major kidney outcomes and a consistent effect across CKD stages

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The GIR increased from 3.21 to 5.16 mg min1 kg1 (p 3 major US claims databases (Medicare, Optum, MarketScan