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A recent post-hoc analysis of SURPASS-3 (NCT03882970) in adults with T2DM reported decreases in fat mass and muscle fat infiltration (MFI) accompanying weight loss [65], suggesting potential improvements in muscle quality that may be especially promising for older adults

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Replicative DNA synthesis, as measured by tritiated thymidine, was elevated in all strains after four days of exposure to phenobarbital

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