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[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Heerspink HJL, et al

Starting both compounds together from baseline If beginning both compounds from scratch, start retatrutide first

GLP-1 receptor activation reduces appetite, slows gastric emptying, promotes insulin secretion from pancreatic beta cells, and creates the characteristic feeling of fullness that GLP-1 agonist users report

Some of these events have been reported in patients without known underlying renal disease

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