Its pharmacological effects stem primarily from the disruption of monoaminergic neurotransmission and its downstream neurotoxic consequences
The same class includes semaglutide products sold in Canada as Ozempic, Wegovy and Rybelsus
Another study on cardiometabolic risk factors in a diabetes case-control study (NCT02588898) and a vitamin-supplementation trial (NCT02586181) found high plasma concentrations of metabolites, including TMAO and choline, correlated with lower cholesterol and plasma phospholipid levels, suggesting TMAO may aid in cholesterol solubilization and macrophage cholesterol (158)
The medications themselves do not directly cause muscle loss the mechanism is indirect: appetite suppression reduces overall food intake, which lowers protein consumption, at the same time that caloric restriction elevates whole-body EAA requirements
10.1128/AEM.03319-14 Appl
They added that the patient's liver enzymes "recovered rapidly" after they stopped taking the pill, which is an oral GLP-1 drug called danuglipron
