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It activates genes involved in DNA repair, stress response, matrix remodeling and antioxidant defense, while suppressing genes associated with inflammation, fibrosis and tissue destruction

Results of this integrated analysis suggest that the triple combination of GLP-1RA, SGLT2i, and finerenone provides stronger cardiorenal protective benefits than either conventional therapy or each alone

This makes it a preferred choice for individuals who seek immediate and potent effects

Most importantly, growth hormone stimulates the production of insulin-like growth factor-1 (IGF-1), a powerful mediator of tissue growth and repair

This counterintuitive finding likely relates to the GIP component moderating GLP-1 induced nausea

PMCID: PMC4633518