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In another study on rat hearts, addition of both insulin and KB to isolated perfused working rat hearts led to a 35% increased efficiency of cardiac hydraulic work (98)

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Antiviral activity of phenformin in vivo Given that phenformin is an established drug in humans with known pharmacokinetics and safety profiles, that is hence readily available, we further evaluated the in vivo antiviral potential of phenformin against SARS-CoV-2 in a Golden Syrian hamster model of infection (Fig

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