Semaglutide GLP-1 receptor agonist analogue used extensively in obesity and metabolic syndrome preclinical research
DOI: 10.26655/JMCHEMSCI.2023.5.25 Abed-Mansoor A.F., Abu-Raghif A.R
Both drugs use semaglutide, a GLP-1 RA, and are manufactured by Novo Nordisk
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Additionally, their under-development triple agonist, Retatrutide, has shown unprecedented weight loss effects in phase 2 clinical trials.16 Matthias Tschp and his team discovered that dual agonists targeting both GLP-1 and GIP receptors (GIPR) are more effective in treating diabetes than those targeting only GLP-1R