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However, specificity is not absolute in vitro SMXL6 and SMXL7, both considered D14-specific substrates, were also able to co-precipitate MAX2 with GST-HTL7 in the presence of GR24 in our pull-down assay (Supplementary Fig

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26 Nonetheless, these ferroptosis inhibitors have been demonstrated to prevent cellular damage and death in a wide range of ex vivo and in vivo models of acute and chronic pathological cell death, 2,13,26,32 and testing in more complex diseases models or human clinical trials should be anticipated in the future