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MIR (10 mg/kg, i.p.) was given 30 min before aripiprazole (0.1 and 0.3 mg/kg i.p.) repeatedly, once daily for 21 days before the tests

NAD+ plays a vital role in redox reactions and sirtuin activation

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Hematoxylin and eosin (H&E) staining revealed notable tumor metastases in the liver from the control, saline, and vesicle groups, but not in the Dox and Dox@vesicles treatment groups

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