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Novel agents that block CGRP or its receptor (anti-CGRP monoclonal antibodies and gepants) are now widely prescribed for migraine prevention and treatment

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Beyond these, several special conditions amplify the ROS burden: : Excess hepatic iron (as in hereditary hemochromatosis or iron overload due to excessive red blood cell transfusions) catalyzes the Fenton reaction (FeIron overload 2 + H 2 O 2 Fe 3 + OH + OH), generating highly reactive hydroxyl radicals

Psychostimulants (METH, cocaine and synthetic cathinones) induce neurotoxicity primarily through disruption of monoaminergic signaling

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