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doi: 10.3389/fphar.2018.01162 Received 30 May 2018 Accepted 24 September 2018 Published 16 October 2018 Volume 9 - 2018 Edited by Andres Trostchansky, Universidad de la Repblica, Uruguay Reviewed by Suowen Xu, University of Rochester, United States

Regulatory authorization for new drug for first indication, defined as Novel Drug Approval by FDA, and Marketing Authorization for New Active Substance by EMA.

The injection should be administered only under medical supervision

138,139 The main transporter genes are SLC22A12 (URAT1), SLC2A9 (GLUT9), and ABCG2 (BCRP)

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Remember these key points: Eat small meals throughout the day Pick bland foods when you feel sick Add fiber slowly to prevent constipation Drink water all day long Avoid greasy, sugary, and spicy foods Listen to what your body tells you Taking tirzepatide is a journey