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The methods were prepared using the Cochrane Handbook and Review Manager (RevMan) version 5.4 software (The Nordic Cochrane Centre, The Cochrane Collaboration, 2020, Copenhagen, Denmark) and this paper was reported using the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement [4448]

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That said, giving the nasal framework stronger and more symmetric support can be an essential part of making breathing easier

This has subsequently been taken forward into Phase 1 clinical trials as ALT-801 ( Table 1 )