Environmental factors such as heavy metal toxicity [1012], sub-clinical viral infections [13] and gastro-intestinal pathology [14, 15], as well as endogenous toxins produced by metabolic processes [16], hormones (reviewed in [17]) and gastro-intestinal bacteria [18, 19] have also been suggested as playing a role in the aetiology of the disorder, although none of these have been thoroughly investigated
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When these bacteria are imbalanced due to antibiotics, chronic stress, or a low-fiber diet, estrogen is reabsorbed instead of eliminated, re-entering circulation and amplifying symptoms of estrogen dominance
9 BalusuS.BrkicM.LibertC.VandenbrouckeR
High amounts of polyunsaturated fatty acids and low levels of antioxidants such as glutathione in nerve cells may render the brain vulnerable to oxidative stress (6)
The buildup of free radicals contributes to a condition called oxidative stress, which is associated with aging and PD
