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[PubMed] [Google Scholar] 16.Ilic S., Drmic D., Franjic S., Kolenc D., Coric M., Brcic L., Klicek R., Radic B., Sever M., Djuzel V., et al

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In hypoxic pulmonary hypertension (HPH), elevated CUL5 expression binds TRAF6 (TNF receptor-associated factor 6), activating the NF-B pathway to stabilize HIF-1, thereby increasing VEGF expression and driving pulmonary vascular remodeling and HPH progression (39)

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Among these, catalase/peroxidase-HPI (log 2 FC = 2.76), superoxide dismutase (log 2 FC = 1.16), glutathione S-transferase (log 2 FC = 1.05) and glutathione transferase theta class (log 2 FC = 0.84), catalase (log 2 FC = 0.89), thioredoxin-dependent peroxide reductase (log 2 FC = 0.74), and thioredoxin-like protein (log 2 FC = 0.67), were all induced as part of stress-induced protective responses (Supplementary Table S1)