C.BostanM.et al (2025)
This research-grade compound is supplied as a lyophilised (freeze-dried) powder , designed to ensure stability, precision, and reproducibility in controlled scientific environments
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Measurement of the levels of intracellular GSH and the relative expression of NRF2, GPX4 and SOD1 in tissue samples following neoadjuvant chemotherapy To further verify the role of GSH metabolism in chemotherapy resistance, we analyzed breast cancer data from the Gene Expression Omnibus (GEO) dataset (GEO: GSE140494)
In contrast, CHAC1-driven GSH degradation reduces protein SSG, enhances transferrin receptor (TFRC)mediated iron uptake, and exacerbates ferroptosis, whereas hemoglobin SSG shields reactive cysteine residues from excessive oxidation 127,128
In addition, a low level of GPx3 is an independent predictive marker of the local recurrence of early-stage invasive breast cancer in patients undergoing breast-conserving surgery and radiotherapy, regardless of the patients clinicopathological parameters [104]