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J Biol Chem (2005) 280:27508.10.1074/jbc.M410242200 41 Gonzalez-DosalRHoranKARahbekSHIchijoHChenZJMieyalJJet alHSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6

The excess production of ROS triggers lipid peroxidation in iris epithelial cell membranes and photoreceptor mitochondria, resulting in inflammation cell chemotaxis and irreversible retinal damage [314, 315]

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The complexities of how BBB dysfunction is linked with extravasated plasma components, including fibrinogen, IgG, albumin, thrombin, and hemosiderin, remain to be fully elucidated [216]

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