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Our paradigm also did not require food deprivation: in contrast to several previous laboratory-based experiments (e.g., [51, 52]), the animals were allowed to eat in an unrestrained and practically ad libitum manner (see Methods)

A recent study yielded additional model predicted targets after including lipid requirements 83

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Initial gains may come quickly as inflammation decreases and blood flow improves, but the deeper tissue remodeling required for lasting resolution takes longer