This was predominantly driven by the continuing roll-out of Novo Nordisks semaglutide and Lillys tirzepatide, and off-label use of their respective T2D-indicated brands
As part of standard of care, 49% of patients received SGLT2i at some point during the trial
These include: Orlistat : A lipase inhibitor that reduces fat absorption, with a different mechanism and side effect profile than appetite suppressants Naltrexone-bupropion : A combination medication affecting reward pathways and appetite regulation Phentermine-topiramate ER (Qsymia) : An FDA-approved combination that has been studied more extensively than phentermine-semaglutide and is approved for long-term use Tirzepatide (Zepbound) : A dual GIP/GLP-1 receptor agonist that has demonstrated greater weight loss than semaglutide in head-to-head clinical trials (SURMOUNT-5) Intensive lifestyle interventions remain foundational to successful weight management
(A) IPGTT
Eine Phase-II-Studie mit der Substanz Retatrutid konnte zeigen, dass alle Probanden in den Kohorten mit den 3 hchsten Dosierungen mindestens 5 % ihres Krpergewichts verloren
Blue Cross Blue Shield plans cover some weight loss medications, yet real-world patients frequently encounter barriers including prior authorization requirements, step therapy protocols, and coverage exclusions
