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Diarrhea affected 24% of the highest dose group, typically presenting during the first four to six weeks of treatment

Elevated levels indicate liver cell damage

This, however, does not apply to other GLP-1RAs approved for the treatment of T2DM, including the same liraglutide (Victoza) and semaglutide (Ozempic or Rybelsus) at lower dosages, prompting several stakeholders to request an updated guidance 232 and more caution in media enthusiasm 233

Side effects such as nausea or stomach upset are common at first but usually decrease over time

Foundational meta-analyses established this bidirectional association [16], and large-scale registry data confirm that the risk is particularly pronounced in metabolically unhealthy obesity [17]

Talk with your healthcare provider or registered dietitian to personalize your plan and achieve your goals.