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It works differently than many currently available treatments because it targets three hormone receptors involved in metabolism and appetite regulation: GLP-1 GIP Glucagon Because of this triple-action mechanism, retatrutide has shown very promising results in early clinical trials, with some participants experiencing significant reductions in body weight

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( K and L ) Intraperitoneal glucose tolerance ( K ) and area under the curve ( L ) in 11- to 18-week-old mice ( n = 68 per group)

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Retatrutide is primarily being developed for obesity treatment, with TRIUMPH trials focusing on weight loss in people with and without diabetes

[1] The Use of Semaglutide in Patients With Renal Failure A Retrospective Cohort Study, Endocrine Practice, October 2024