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Step 1: Calculate the concentration Concentration = 10 mg / 2 ml = 5 mg/ml Step 2: Calculate the volume for your desired dose Volume = 4 mg / 5 mg/ml = 0.8 ml Result: You need to draw up 0.8 ml to deliver 4 mg

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As of 2023, there are no peer-reviewed, randomised controlled trials published in reputable medical journals that demonstrate berberine patches achieve clinically meaningful systemic absorption or produce therapeutic effects comparable to oral formulations

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And even those were arduous for me