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Galy B, Conrad M, Muckenthaler M (2023) Mechanisms controlling cellular and systemic iron homeostasis

Based on the fact that IR and IGF-1R are abundantly expressed in chondrocytes 27,28 and the previous work which showed upregulation of IR signaling in osteoblasts lacking IGF-1R, 12 we suspected that the increased proliferation of IR-deficient growth plate chondrocytes could be caused by upregulation of the IGF-1/IGF-1R signaling pathway

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We observed an increase in intracellular GSH content in cells treated with 100 M of -EC, GSH, or UDE containing 100 M -EC, compared to the untreated control cells (Fig

However, this study has several limitations