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doi: 10.3389/fcell.2021.722412 47 NunesSCLopes-CoelhoFGouveia-FernandesSRamosCPereiraSASerpaJ

In REDEFINE and CagriSema research, the drug candidate as monotherapy reached roughly 11.8 percent body-weight reduction

Adipose tissue-derived free fatty acids (FFAs) impair renal urate excretion via URAT1 upregulation, while hyperuricemia reciprocally induces insulin resistance and endothelial dysfunction through AMPK inhibition and oxidative stress (Xu et al., 2015)

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[PubMed] [PMC] Zidan A, Hedya SE, Elfeky DM, Abdin AA (2018) The possible anti-apoptotic and antioxidant effects of acetyl l-carnitine as an add-on therapy on a relapsing-remitting model of experimental autoimmune encephalomyelitis in rats