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Tirzepatide may produce greater average weight loss for some individuals because it activates two hormone pathways, GLP-1 and GIP, while semaglutide targets only the GLP-1 receptor

Nevertheless, multiple degradation-resistant and structurally distinct GLP-1RAs do not generate the same GLP-1 metabolites yet reduce blood pressure, increase heart rate, inhibit enterocyte chylomicron secretion and reduce the extent of myocardial infarction in rats and mice through mechanisms requiring the canonical GLP-1R [99, 105,106,107,108]

Endocrinology 121 , 10761082 (1987)

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The powerful antioxidant trio of alpha lipoic acid, N-acetyl cysteine and acetyl L-carnitine are shown to recharge cellular energy production and the primary cellular antioxidant pools of vitamins E, C and glutathione