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Cureus 15 , e37266 (2023)
Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025
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But there may be some people who are sensitive, and then they get a reflex increase in gut motility. Dose adjustments Side effects like indigestion and bowel problems are commonest when people start taking the medication, as their body gets used to it, said Professor Mike Lean, an obesity specialist at the University of Glasgow
BFRs are also of concern due to their widespread occurrence in the environment and adverse effects on living organisms, including humans
