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The breadth of gene-expression modulation documented in Pickart 2015 is unusual

Oral supplementation is preferable here, since smaller, oral doses are often better tolerated by the body

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Novo and Lilly also noted that altering the drug design, as suggested by some plaintiffs, would require FDA action

Positive cardiovascular outcomes would strengthen the case for dual agonism as a preferred therapeutic approach, particularly in high-risk patients