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10.1002/smll.201870106 23 BarbalinardoM.CaicciF.CavalliniM.GentiliD

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Other than redox-dependent regulation of membrane receptors for coronaviruses, mito-ROS are also instigators of aberrant vacuole formation (Demers-Lamarche et al., 2016) by activation of adaptor-associated kinase 1 (AAK1), a regulator of endocytosis (Chen et al., 2006) that has been targeted therapeutically in SARS-CoV-2 infection with baricitinib (Stebbing et al., 2020)

It activates cytoprotective mechanisms within cells in a hormetic-type response

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PMID 13678070