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2 Because placebo effects are common in controlled trials conducted with IC/BPS patients, any apparent procedural deviations that could compromise the integrity of randomization or blinding resulted in a rating of increased risk of bias for that particular trial

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Shortness of Breath Low levels of vitamin B12 may result in reduced oxygen-carrying capacity and consequently cause shortness of breath during physical exertion

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Injection-site and systemic: injection-site reactions 13%, upper respiratory infection 21%, hypersensitivity 10%, fluid overload 12%, decreased appetite 7%, sleep disturbance 5% [1]