does tirzepatide affect heart rate GLP-1 Agonists and Does Tirzepatide Shrink Your Heart?

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GLP-1 receptor agonist drugs (called GLP-1s for short) like semaglutide work by mimicking this hormone, increasing insulin release (which helps control diabetes), signaling your brain that you're full, and slowing digestion

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Key findings (Vafaei et al., 2025): 30-50 mg/kg mirtazapine: dose-dependent seizure suppression Mediated by CB1/CB2 activation (proven by antagonist blockade) GABA-independent mechanism (distinct from benzodiazepines) Appetite/weight gain provides in-vivo functional validation of CB1 engagement The broader implication: Clinicians and researchers have been using ECS pharmacologyunknowinglyfor decades