Lgr5 + stem cells divide into proliferating transit-amplifying (TA) cells, each of which can differentiate into either a secretory or absorptive progenitor cell
Mechanistically, GLP-1 preserved LV function and LV mass, promoted myocardial glucose utilization, and attenuated cardiomyocyte apoptosis (35)
In the phase 2b trial, however, the reductions in glycated hemoglobin and body weight in participants treated with NNC0090-2746 were similar to those in the group treated with liraglutide (76), and no phase 3 trial of NNC0090-2746 has been reported yet
Efficacy and Safety of Liraglutide and Semaglutide on Weight Loss in People With Obesity or Overweight: A Systematic Review
It is always best to consult with your healthcare provider before starting GLP, especially if you are taking other medications or have any existing health conditions
It slows stomach emptying which leads to a slower flow of sugar from the bloodstream to your stomach, ultimately reducing the risk of a blood sugar spike