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The definitive 24-week Phase III trial in 534 obese participants, testing doses of 0.25mg, 0.5mg and 1.0mg daily, did not produce statistically significant weight loss over placebo

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(4) Notably, exposing wound models to the peptide has been linked with fewer infiltrating inflammatory cells and lower tissue levels of key inflammatory mediators such as leukotriene B4, thromboxane B2, and myeloperoxidase

These clinical findings suggest the enzymatic activity of SIRT1 was reduced in specific brain regions that increase vulnerability to the effect of neurotoxins

GBD 2021 Adolescent BMI Collaborators

Benek, O., Korabecny, J