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The HLA ligands in frame 23 could be related to three human proteins at its TCR face, including peptides derived from parathyroid hormone, WASH complex, and desmocollin-1

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In this context, DHODH, a mitochondrial inner-membrane enzyme traditionally known for its role in de novo pyrimidine biosynthesis, was proposed to also function as a CoQ 10 oxidoreductase and ferroptosis suppressor