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Trajectories of percentage BMI change during the 12 months after semaglutide initiation stratified by (A) semaglutide dose, (B) sex, (C) type 2 diabetes status, and (D) baseline BMI
The GLP-1 story is one were watching closely because it validates what our clinical team has long understood: the body and mind dont operate in separate silos
3 However, the short half-life of native GLP-1 has limited its therapeutic use for diabetes
doi: 10.1038/s41598-017-17204-5 24 FranssonLDos SantosCWolbertPSjoholmARafachoAOrtsaterH
its about unlocking a level of biological synergy that neither compound can achieve on its own
247 Mechanistically, it is unclear how GLP-1-based therapies exert beneficial effects on the cardiovascular system, but studies have suggested that this is achieved by direct (cardiovascular GLP-1R activation) and indirect (promotion of the incretin effect) mechanisms
