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In the LEADER trial, a total of 9,340 subjects with T2D and high CV risk were randomized to liraglutide or placebo and followed-up for a median of 3.8 years (100)

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The poor oral bioavailability of BBR is compromised by P-glycoprotein (P-gp), an active efflux protein that depletes adenosine triphosphate and extrudes BBR into the intestinal lumen, thereby limiting its absorption

The most commonly reported side effects are minor and short-lived