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10.1016/j.molmet.2019.09.010 [DOI] [PMC free article] [PubMed] [Google Scholar] Nakabayashi, H

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It is the world's first sustained-release GIP/GLP-1 receptor agonist for the treatment of type 2 diabetes that activates both the GLP-1 and GIP receptors

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In addition, preclinical evidence suggests -TOH administration mitigates astrocytic reactivity and microglial NLRP3 inflammasome activation, thereby attenuating neuroglial crosstalk-driven excitotoxic cascades

Analyses were performed using SPSS 23.0 (IBM, Armonk, NY, United States) statistical software