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At the end of the 36-week tirzepatide lead-in period, participants achieved 21.1% mean WL

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Burnier, M

Potential side effects are rare and usually mild, such as slight discomfort at the IV site

Nausea typically improves significantly, becoming milder or less frequent

Additionally, individuals with a history of Multiple Endocrine Neoplasia syndrome type 2 (MEN2) should not pursue GLP-1 treatment due to inherited thyroid cancer risk