Where it works: Liver: Increases hepatic glucose production and fat oxidation (when carbs are low) Adipose tissue: Stimulates lipolysis (breakdown of stored fat into free fatty acids) Brown adipose tissue: Activates thermogenesis (heat production from burning fat) Muscle: May increase fat oxidation during exercise Weight loss contribution: The glucagon component appears to add an additional 2-3% weight loss beyond the GLP-1/GIP combination (24% vs 22% for tirzepatide)
While Foundayo is well-tolerated by most people, some should not take the drug, including: Those with a history or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or other thyroid cancers should not take Foundayo
N Engl J Med 2020;383:221929.PubMed 101
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