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At the current stage, their most likely role appears to be as an adjunctive therapy, particularly in patients with skin diseases coexisting with obesity or diabetes, the review authors conclude

Collectively the results from these studies will be valuable in better assessing the benefits of metformin on healthspan and also fine-tuning future larger studies such as TAME

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Data Availability Sharing is not applicable to this article as no datasets were generated or analyzed during the current study

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In contrast, greater MP was reached on all bouts with the 1.5 g/d dosage with gains across the five sprints of +4.9%, +1.7%, +2.7%, +2.9%, and +5.1% compared with baseline