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PKA directly phosphorylates sulfonylurea receptor 1 (SUR1), a regulatory subunit of voltage-dependent K + channels and KATP channels, increasing membrane depolarization and voltage-gated Ca 2+ channel activation

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V.et al (2012)

This provided a rationale for combining GLP-1R agonists, which effectively lower blood glucose in T2D, with GIPR agonists

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Many patients report that taking their GLP-1 injection during the first few days of menstruationwhen hormone levels are lowestproduces fewer side effects