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Impaired astrocyte function can result in decreased elimination of extracellular glutamate, leading to a reduced seizure threshold and an imbalance between neuronal excitation and inhibition (Bialer & White, 2010)

1 Introduction With the advancement of the social economy and alterations in lifestyle patterns, chronic metabolic disorders like obesity and diabetes have emerged as major public health issues ( Type 2 diabetes mellitus (T2DM) is typically characterized by a gradual decline in -cell function, often rooted in insulin resistance ( Metabolic reprogramming represents the process wherein an organism modifies its energy metabolism pathways, such as transitioning from glucose metabolism to fatty acid oxidation or other metabolic routes, in response to environmental alterations or disease conditions

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10.1192/bjpo.bp.116.003756 34