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This strategy provides both high local concentration and broader systemic support

GLP-1 receptor agonists slow gastrointestinal motility throughout the digestive tract, prolonging transit time and allowing more water absorption from stool in the colon

The study also found that for every one percentage point of weight gain after stopping, the likelihood of restarting the medication increased by 2.3% to 2.8%

Shah, n.d.)

Injectable semaglutide, sold by Novo Nordisk under the brand name Wegovy for weight loss, and tirzepatide, sold by Eli Lily as Zepbound for weight loss, generally cap out at a 15-20% body weight loss for the highest doses and 5-10% on the lower end

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