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Pembrolizumab was discontinued because of adverse events in 7% of the patients treated with 2 mg/kg, with 3% considered drug-related adverse events by the investigators

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The primary end points for part one were (1) resolution of steatohepatitis without worsening of liver fibrosis, and (2) reduction in liver fibrosis without worsening of steatohepatitis Primary outcome: Results In patients with MASH and moderate or advanced liver fibrosis, once-weekly semaglutide at a dose of 2.4 mg improved liver histologic results

Patients receiving tirzepatide showed 55% improvement in sleep apnea symptoms compared to 5% improvement with placebo ^17

iScience 26:105717 Kriston L, von Wolff A, Westphal A, Holzel LP, Harter M (2014) Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis