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Differential observations suggest that the role of caveolin 1 in hepatic lipid accumulation may differ depending on how the steatosis is induced, e.g., via high fat diet or fasting

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GSH directly neutralizes reactive oxygen species (ROS), including hydrogen peroxide (HO) and lipid peroxides, and contributes to the detoxification of xenobiotics and electrophilic compounds through conjugation reactions mediated by glutathione S-transferases (GSTs) [36]

Concurrent nutritional deficienciesparticularly folate or iron deficiencycan impair the response to B12 treatment, as these nutrients work together in red blood cell production

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