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[DOI] [PMC free article] [PubMed] [Google Scholar] Runge S, Thgersen H, Madsen K, Lau J, Rudolph R

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In a mechanism of action study that aimed to achieve 10% body weight reduction in participants with obesity who were without T2D, tirzepatide was compared to placebo for sleeping and 24-h energy expenditure and respiratory exchange ratio by utilizing metabolic chambers assessed at baseline and after 18 weeks [56]

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Nat Commun (2022) 13(1):5782