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Pharm Biol 50(8):10071012 Lee DU, Kang YJ, Park MK, Lee YS, Seo HG, Kim TS, Kim CH, Chang KC (2003) Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages

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During mastication they are enzimatically converted into thiocyanates, goitrin metabolites, that cause a competitive inhibition of the sodium/iodide symporter, thus inhibiting the thyroid hormones synthesis and possibly causing hypothyroidism [156]

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