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doi: 10.1677/JOE-09-0132 46 GilmanCPPerryTFurukawaKGriegNHEganJMMattsonMP

This formed the basis for Black's development of the first beta-blocker, propranolol, at Imperial Chemical Industries, a chemical conglomerate with pharmaceutical laboratories in Cheshire that he joined in 1958 and stayed with until 1964 when he moved to Smith Kline and French, an American pharmaceutical company with laboratories in Hertfordshire, South East England

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This article mainly introduces the current R&D direction and optimization strategies of GLP-1, and illustrates its bioanalytical challenges and strategies for GLP-1 analogues