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Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

Itll feel slow sometimes but just keep doing the little things that you can, little walks etc add up

Among the 12mg group, 58.6% achieved 25% or greater weight loss, 39.4% achieved 30% or greater, and 23.7% achieved 35% or greater

Clinical decision-making should consider the totality of cardiovascular risk factors rather than focusing exclusively on lipid parameters

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